EORTC 30904
For small localized RCC, can nephron-sparing surgery preserve renal function without compromising cancer outcomes?
What changes for patients?
In the ITT population, 10-year OS was 75.7% with nephron-sparing surgery vs 81.1% with radical nephrectomy. The trial did not establish non-inferiority. Only 12 of 117 deaths were renal-cancer deaths, and renal function was substantially better after NSS. This study should not be interpreted as evidence that partial nephrectomy is oncologically inferior in modern appropriately selected cT1 RCC.
NNT: Not applicable; non-inferiority not demonstrated
Moderate renal dysfunction
NNH: Not applicable; renal dysfunction favoured NSS
HR: 1.50 for NSS vs RN
95% CI 1.03–2.16; non-inferiority P=.77
The trial did not establish an overall-survival advantage for nephron-sparing surgery, but renal-function preservation remains important and partial nephrectomy is standard for suitable T1 tumours.
- Van Poppel H, et al. Eur Urol. 2011;59:543–552.
- Scosyrev E, et al. Eur Urol. 2014;65:372–377.
- Primary publication / source
- Primary publication / source